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Diamine oxidase activity levels in anorexia nervosa

DAO levels in AN-R patients were significantly lower than in AN-BP patients and healthy controls.

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 2014 Mar;47(2):203-5. doi: 10.1002/eat.22202. Epub 2013 Oct 30.

Takimoto Y1, Yoshiuchi K, Shimodaira S, Akabayashi A.

Author information

1
Department of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Abstract

OBJECTIVE:

Anorexia nervosa (AN) patients often experience gastrointestinal complications caused by their malnutrition. We hypothesized that intestinal integrity is disturbed in AN. Therefore, the objective of the present study was to investigate serum diamine oxidase (DAO) activity, which is considered to be a clinical indicator of the integrity of the intestinal mucosa, in AN patients.

METHOD:

Thirty-six AN female patients including 21 AN restricting type (AN-R) and 15 AN binge-eating/purging type (AN-BP) were compared with twenty healthy women on serum DAO activity using immunoassay.

RESULTS:

DAO levels in AN-R patients were significantly lower than in AN-BP patients and healthy controls.

DISCUSSION:

DAO levels were decreased in AN-R patients. This finding suggests the presence of intestinal structural disturbance as one of the physical complications of malnutrition in AN-R patients.

Copyright © 2013 Wiley Periodicals, Inc.

PMID: 24488839 DOI: 10.1002/eat.22202