DAO y síntomas inmunológicos

DAO y síntomas inmunológicos

Liberación masiva de la enzima diamina oxidasa que degrada la histamina durante la anafilaxia grave en pacientes con mastocitosis

La actividad histaminolítica mediada por la diamina oxidasa (DAO) está presente en el plasma después de la inducción de anafilaxia severa en ratas, cobayas y conejos. La heparina liberada durante la desgranulación de mastocitos en el tracto gastrointestinal podría liberar DAO de los sitios de almacenamiento sensibles a la heparina.

Serum levels of histamine and diamine oxidase in multiple sclerosis

Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system, mostly affecting young adults. Diamine oxidase is an enzyme essential for histamine production. Histamine which is produced mostly by mast cells can have effects on different aspects of immune system via its different histamine receptors (H1R, H2R, H3R and H4R).

DAO y síntomas cardiovasculares

Microbial patterns in patients with histamine intolerance

Histamine intolerance represents a controversially discussed disorder. Besides an impaired degradation of orally supplied histamine due to diamine oxidase (DAO) deficiency, a deranged gut flora may also contribute to elevated histamine levels

Histamine-reduced diet and increase of serum diamine oxidase correlating to diet compliance in histamine intolerance

Diagnosis of histamine intolerance (HIT) has been based on low serum diamine oxidase (DAO) values, functional gastrointestinal disorders and improvement of symptoms with a histamine-reduced diet (HRD). In a retrospective analysis of outpatients’ charts we identified 101 patients with HIT. After a median of 13 months, a questionnaire was distributed to the patients so that they could be classified into four diet-compliance groups.

Serum Diamine Oxidase in Pseudoallergy in the Pediatric Population

Histamine intolerance (pseudoallergy) is a poorly investigated type of food hypersensitivity. The main enzyme responsible for histamine degradation in the extracellular matrix is diamine oxidase (DAO). Disturbances in the concentration or activity of DAO may lead to the development of clinical signs of allergy.

A Popular myth – low-histamine diet improves chronic spontaneous urticaria – fact or fiction?

A total of 75% of the patients had a benefit from the low-histamine diet. Thirty-four of 56 patients (61%) reached the primary endpoint of the study, an improvement of UAS 4 of ≥3. Overall, a significant reduction from 9.05 to 4.23 points (P = 0.004) was achieved; the average reduction in a strongly affected subgroup was 8.59 points (P < 0.001). DAO activity remained stable.

Tyramine and histamine risk assessment related to consumption of dry fermented sausages by the Spanish population

Tyramine and histamine are the main dietary bioactive amines related to acute adverse health effects. Dry fermented sausages can easily accumulate high levels of these hazards and are frequently consumed in Spain. The present work aims to assess the exposure to tyramine and histamine from the consumption of dry fermented sausages by the Spanish population and to assess the risk to suffer acute health effects from this exposure.