DAO y síntomas neurológicos

Association of Diamine oxidase (DAO) variants with the risk for migraine
DAO y síntomas neurológicos

Association of Diamine oxidase (DAO) variants with the risk for migraine from North Indian population

Migraine is a common neurovascular disorder affected by various levels of neurotransmitters. Low histamine metabolism is also related with pathophysiology of migraine.

As diamine oxidase (DAO) gene variants are linked with higher levels of histamine in migraine patients, we investigated the possible relationship of two variants rs2052129 and rs10156191 of this gene with migraine risk in North Indian population.

DAO y síntomas neurológicos

Migraines appear more likely to be caused by histamine rather than ethanol

We read with interest the manuscript by Onderwater et al. that reported on alcoholic beverages as a trigger factor for migraines [1]. Although, epidemiological studies have found a correlation between alcohol intake and headaches, a specific pathophysiologic mechanism of this headache remains unidentified [2].

Serum levels of histamine and diamine oxidase in multiple sclerosis

Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system, mostly affecting young adults. Diamine oxidase is an enzyme essential for histamine production. Histamine which is produced mostly by mast cells can have effects on different aspects of immune system via its different histamine receptors (H1R, H2R, H3R and H4R).

DAO y síntomas cardiovasculares

Microbial patterns in patients with histamine intolerance

Histamine intolerance represents a controversially discussed disorder. Besides an impaired degradation of orally supplied histamine due to diamine oxidase (DAO) deficiency, a deranged gut flora may also contribute to elevated histamine levels

Histamine-reduced diet and increase of serum diamine oxidase correlating to diet compliance in histamine intolerance

Diagnosis of histamine intolerance (HIT) has been based on low serum diamine oxidase (DAO) values, functional gastrointestinal disorders and improvement of symptoms with a histamine-reduced diet (HRD). In a retrospective analysis of outpatients’ charts we identified 101 patients with HIT. After a median of 13 months, a questionnaire was distributed to the patients so that they could be classified into four diet-compliance groups.