Evidencia científica

Publicaciones científicas sobre
Déficit de DAO y sus patologías asociadas

Serum levels of histamine and diamine oxidase in multiple sclerosis

Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system, mostly affecting young adults. Diamine oxidase is an enzyme essential for histamine production. Histamine which is produced mostly by mast cells can have effects on different aspects of immune system via its different histamine receptors (H1R, H2R, H3R and H4R).

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DAO y síntomas inmunológicos, DAO y síntomas neurológicos, Ensayos y estudios Clínicos, Publicaciones Científicas

Biogenic Amines in Plant-Origin Foods: Are they Frequently Underestimated in Low-Histamine Diets?

Low-histamine diets are currently used to reduce symptoms of histamine intolerance, a disorder in histamine homeostasis that increases plasma levels, mainly due to reduced diamine-oxidase (DAO) activity. These diets exclude foods, many of them of plant origin, which patients associate with the onset of the symptomatology.

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DAO y síntomas cardiovasculares, DAO y síntomas dermatológicos, DAO y síntomas gastrointestinales, DAO y síntomas inmunológicos, DAO y síntomas neurológicos, Fundamentos biológicos del Déficit de DAO, Publicaciones Científicas

Microbial patterns in patients with histamine intolerance

Histamine intolerance represents a controversially discussed disorder. Besides an impaired degradation of orally supplied histamine due to diamine oxidase (DAO) deficiency, a deranged gut flora may also contribute to elevated histamine levels

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DAO y síntomas cardiovasculares, DAO y síntomas dermatológicos, DAO y síntomas gastrointestinales, DAO y síntomas inmunológicos, DAO y síntomas neurológicos, Ensayos y estudios Clínicos, Fundamentos biológicos del Déficit de DAO

Conformational Design and Characterisation of a Truncated Diamine Oxidase from Arthrobacter globiformis

A functional mini protein can be developed by miniaturising its size. The minimisation technique provides an excellent model system for studying native enzymes, especially in creating an alternative novel biocatalyst. Miniaturised proteins may have enhanced stability, a crucial characteristic for large-scale production and industrial applications.

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Fundamentos biológicos del Déficit de DAO, Publicaciones Científicas

Histamine-reduced diet and increase of serum diamine oxidase correlating to diet compliance in histamine intolerance

Diagnosis of histamine intolerance (HIT) has been based on low serum diamine oxidase (DAO) values, functional gastrointestinal disorders and improvement of symptoms with a histamine-reduced diet (HRD). In a retrospective analysis of outpatients' charts we identified 101 patients with HIT. After a median of 13 months, a questionnaire was distributed to the patients so that they could be classified into four diet-compliance groups.

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Low-histamine diet supplemented with exogenous diamine oxidase enzyme is useful for treating migraine in patients with DAO Deficiency

Low-histamine diets and/or exogenous diamine oxidase (DAO) supplementation are currently used to treat symptoms of histamine intolerance (IH), a disorder in histamine homeostasis that increases its plasma levels, mainly dou to DAO deficiency. Headache is the most recognized symptoms.

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Congresos y conferencias, DAO y síntomas neurológicos, Ensayos y estudios Clínicos, Publicaciones Científicas

What about legumes as a plant source of the DAO enzime?

The use of exogenous diamine oxidase (DAO) enzyme has been recently postulated as a potential strategy for the treatment of histamine intolerance, a disorder in the homeostasis of histamine caused by a reduction of its intestinal degradation. Dietary supplements based on gastro-resistant encapsulated porcine kidney protein extract ara available on the market to reduce the symptoms of this intolerance. Although with scarce scientific research, there are some references about the potential of pea seedlings as a source of DAO.

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Congresos y conferencias, DAO en la dieta, Fundamentos biológicos del Déficit de DAO, Publicaciones Científicas

Plasma concentration of diamine oxidase (DAO) predicts 1-month mortality of acute-on-chronic hepatitis B liver failure

The plasma DAO level of survivals [14.0 (7.1; 26.5) ng/mL] was significantly lower than the nonsurvivals [58.6 (32.5; 121.3) ng/mL, P < .001]. The plasma DAO level, hepatic encephalopathy, spontaneous bacterial peritonitis and model for end-stage liver disease (MELD) score were independent factors associated with the 1-month mortality for ACHBLF.

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Ensayos y estudios Clínicos, Fundamentos biológicos del Déficit de DAO, Publicaciones Científicas

Diamine Oxidase Supplementation in Chronic Spontaneous Urticaria: A Randomized, Double-Blind Placebo-Controlled Study

Diamine oxidase (DAO) catabolizes and inactivates histamine, a key player in a wide range of invalidating conditions, such as migraine and chronic spontaneous urticaria (CSU). The highest expression of DAO occurs in the gastrointestinal tract, possibly to control the burden of histamine intake from food.

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DAO y síntomas dermatológicos, Ensayos y estudios Clínicos, Publicaciones Científicas

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Publicaciones científicas sobre Déficit de DAO y sus patologías asociadas

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Publicaciones científicas sobre
Déficit de DAO y sus patologías asociadas