Evaluation of Diamine Oxidase deficiency in patients with migraine

Migraine is a complex, recurrent and disabling disease, but its etiopathogeny remains unknown, so it is necessary to find new approaches to the biochemical mediators of the disease. Histamine, one of the most important mediators, is mainly metabolized by DAO (Diamine Oxidase enzyme). Therefore, it is believed that a decrease in DAO activity may cause histamine excess, increasing the risk of suffering from clinical pictures such as migraine, among others.

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Vidal Carou ● A1, Sabater Sales ● B2, Titus Albareda ● C3.

(A1) Nutrition and Bromatology Department of University of Barcelona.

(B2) MD in Pharmacy. Responsible for scientific research at Sabater Analysis (LABCO).

(C3) Honorary Member of the Spanish Society of Neurology, and Scientific Advisor of the Spanish Association of Headache Patients, AEPAC

3-2-2015

Introduction

Migraine is a complex, recurrent and disabling disease, but its etiopathogeny remains unknown, so it is necessary to find new approaches to the biochemical mediators of the disease. Histamine, one of the most important mediators, is mainly metabolized by DAO (Diamine Oxidase enzyme). Therefore, it is believed that a decrease in DAO activity may cause histamine excess, increasing the risk of suffering from clinical pictures such as migraine, among others.

Objective

To determine the rate of migraine patients presenting DAO deficiency compared to the observed rate in general population without migraine.

Method

Target population consisted of migraine volunteers. Healthy controls were selected among volunteers of their micro social environment. Given a total sample size of 160 individuals, the studied aimed to determine DAO activity level in the participants by analytical determination using a validated procedure.

Materials

IHS diagnostic sheet, patient information sheet, informed consent form, 160 analytical tests to determine DAO, data collection logbook, documents for the registration in the data protection agency.

Resuls

48.8 % of migraine patients presented values of much reduced DAO activity, and 46% of reduced activity. 95% of migraine patients experienced other symptoms related to histamine intolerance. The average value obtained for DAO activity is lower in the migraine group, with a significant difference (p=0.001).

Conclusion

The results confirm the scope of the research and show that DAO activity is significantly lower in migraine patients compared to controls.

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Several foods provoke histamine accumulation in the organism, but not all are necessarily rich in this amine. High intakes of foods rich in other amines such as putrescine,

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