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Partnering

DR Healthcare creates strategic, solid, and successful alliances with other companies and research institutions. All this in order to develop knowledge and promote innovation, and facilitate access to our dietary management and diagnostic solutions for the DAO Deficiency patient population.

Leader in DAO enzyme (DiAmino Oxidase).

As a leader in DAO technology, we market two variants of DAO active ingredient under the trade name adiDAO®.

Thanks to our ongoing research into enzyme extraction and purification, our DAO active ingredient is more efficient and has higher enzymatic activity and stability than our competitors’ DAO extracts.

Hence, we are pioneers in the knowledge of Diamine Oxidase, backed by 15 years of research and development. We have a specific enzyme production plant that complies with GMP’s for the exclusive production of the active ingredient DAO of animal and vegetable origin, with physically separate production units.

These two active ingredients are suitable for the formulation of food supplements, foods for special medical use and medicines. AlsoAlso, for incorporation into different solid or liquid food matrices. All indicated for the dietary management of DAO Deficiency and its associated symptoms.

Tailor-made solutions

Our solutions based on Diamine Oxidase are adapted to the new food control regulations, which stipulate the control of histamine levels in order to avoid the risk of intoxication due to the consumption of high amounts of this biogenic amine present in food.

Food industry sector

The FAO and WHO and countries around the world have implemented regulations that include the analysis of foods that may contain high levels of histamine and measures to prevent its production through proper storage, processing and distribution.

Veterinary and animal health sector

Veterinary solutions based on Diamine Oxidase for the dietary management of histaminosis and DAO Deficiency in pets, livestock and aquaculture. Their health is everyone’s health, hence it is vital to control the pathophysiological effects that trigger elevated histamine levels.

Leading industrial property

Our more than 100 patents give our customers the necessary legal protection in the marketing of final products containing DAO enzyme.

    • DR Healthcare is a world leader in DAO technology with more than 100 patents worldwide.
    • DR Healthcare’s DAO Industrial Property covers the dietary management of migraine, fibromyalgia, ADHD and digestive disorders caused by DAO Deficiency
    • DR Healthcare’s Industrial Property protects the exclusive use of the DAO enzyme in a wide number of health applications and its galenic formulation worldwide.

Regulatory framework in the EU

adiDAO® is a protein extract from pig kidney rich in DAO ingredient authorized as “Novel Food” for use in Food for Special Medical Purposes and in food supplements.
adiDAO® Veg is a vegetable ingredient approved for use in Food for Special Medical Purposes and in food supplements.

DAO Diagnostic Laboratories

The DAO® ANALYTICS is an in vitro diagnostic test to measure the level of DAO (Diamine Oxidase) enzyme activity in plasma. Their results determine a reduced DAO enzyme activity when the values of HDU/ml (Histamine Degraded Units/millilitre of blood) are between 80-40 HDU/ml, or very reduced when they are lower than 40 HDU/ml.

RELATED INFO

Histamine in food

Several foods provoke histamine accumulation in the organism, but not all are necessarily rich in this amine. High intakes of foods rich in other amines such as putrescine,

Que es el Déficit de DAO
What is DAO Deficiency?

DAO Deficiency is an alteration in the metabolism of food histamine that occurs when the activity of the Diamine Oxidase (DAO) enzyme is reduced. That is, when for

Histamine in food

Several foods provoke histamine accumulation in the organism, but not all are necessarily rich in this amine. High intakes of foods rich in other amines such as putrescine,

Que es el Déficit de DAO
What is DAO Deficiency?

DAO Deficiency is an alteration in the metabolism of food histamine that occurs when the activity of the Diamine Oxidase (DAO) enzyme is reduced. That is, when for