Ginger, as a potent anti-inflammatory that is, has been used for thousands of years to treat migraine. Recent studies show that their use is safe.
Therefore, it would be interesting to use ginger as palliative treatment if you have a migraine and a low histamine diet supplemented with enzyme DAO as a preventive treatment.
Download the pdf of the original article from La Razón (health/Alimentation)
Some diseases may have an effect on the DAO enzyme that degrades histamine.
A study by the head of the Gastroenterology and Nutrition Unit of Hospital Chiron Barcelona, Ramon Tormo Carnicé and nutritionist and dietitian Adriana Duelo has revealed that a diet low in histamine supplemented with the enzyme diamine oxidase(DAO) improves the migraine headaches and digestive disorders and skin.
Download the pdf of the original article in the DIARIO DE SEVILLA
A diet low in histamine and supplemented with the enzyme Diamino oxidase (DAO) improves migraine and other associated digestive disorders, according to a study presented by the head of the Gastroenterology and Nutrition Unit of Hospital Chiron Barcelona, Ramon Tormo.
Conference “Migraine and other functional symptoms of DAO deficiency” in INFARMA 2015 on Wednesday 25 March.
Realized by Dr. Ramón Tormo Carnicé, especialist in Gastroenterology and Chief of the Gastroenterology and Nutrition Unit of the Hospital Quirón of Barcelona, and by Adriana Duelo, Dietist-Nutricionist, especialist in DAO deficiency.
27 march 2015 – DR healthcare – Language: Spanish
Read the original article in LA VANGUARDIA
New research led by Dr. Ramon Tormo, Chief of Gastroenterology and Nutrition Hospital Chiron Barcelona, attributed migraine to reaffirm deficit DAO enzyme.
Diamine oxidase rs10156191 and rs2052129 variants are associated with the risk for migraine.
- Department of Biochemistry and Molecular Biology, University of Extremadura, Cáceres, Spain; Red de Investigación de reacciones adversas a alergenos y fármacos, Instituto de Salud Carlos III, Madrid, Spain.
Histamine has been implicated in the pathogenesis of migraine. We investigated the possible association between functional single nucleotide polymorphisms (SNPs) in the diamine oxidase gene (DAO; chromosome 7q36.1, involved in histamine metabolism) and the risk for migraine.
We studied the frequency of the rs2052129, rs10156191, rs1049742, and rs1049793 genotypes and allelic variants in 197 patients with migraine and 245 healthy controls using a TaqMan-based qPCR Assay.
The DAO SNP rs10156191, which is related to decreased DAO enzyme activity, is associated with the risk of developing migraine, particularly in women. The odds ratio (OR) for the defect allele positivity is 1.61 (95% confidence interval 1.31-2.37) for overall migraine patients and 2.08 (1.29-3.36) for women suffering from migraine. The association was not influenced by confounders such as the age at onset, the presence of aura, positivity of alcohol as a triggering factor, positive family history of aura, or family history of allergy. Multiple regression analyses did not confirm association with the rest of genetic factors.
Our findings, which should be framed as hypothesis generating, suggest that DAO genotypes and allelic variants are associated with the risk for migraine in Caucasian Spanish people, especially in women.
© 2015 American Headache Society.
biomarker; diamine oxidase gene; genetics; histamine; migraine; risk factor
Published the 19 feb. 2015 – paratodosla2 –Nutrición y Salud – Language: Spanish.
Eulàlia Vidal, expert in nutrition, speaks about foods that can generate adverse reactions in pleople with histamine intolerance, a molecule that acts in the organism as an hormone and a neurotransmitter and can cause some pathological symptoms. (@paratodosla2 18/02/2015)
Evaluation of Diamine Oxidase deficiency in patients with migraine.
Vidal Carou ● A1, Sabater Sales ● B2, Titus Albareda ● C3.
(A1) Nutrition and Bromatology Department of University of Barcelona.
(B2) MD in Pharmacy. Responsible for scientific research at Sabater Analysis (LABCO).
(C3) Honorary Member of the Spanish Society of Neurology, and Scientific Advisor of the Spanish Association of Headache Patients, AEPAC
Migraine is a complex, recurrent and disabling disease, but its etiopathogeny remains unknown, so it is necessary to find new approaches to the biochemical mediators of the disease. Histamine, one of the most important mediators, is mainly metabolized by DAO (Diamine Oxidase enzyme). Therefore, it is believed that a decrease in DAO activity may cause histamine excess, increasing the risk of suffering from clinical pictures such as migraine, among others.
To determine the rate of migraine patients presenting DAO deficiency compared to the observed rate in general population without migraine.
Target population consisted of migraine volunteers. Healthy controls were selected among volunteers of their micro social environment. Given a total sample size of 160 individuals, the studied aimed to determine DAO activity level in the participants by analytical determination using a validated procedure.
IHS diagnostic sheet, patient information sheet, informed consent form, 160 analytical tests to determine DAO, data collection logbook, documents for the registration in the data protection agency.
48.8 % of migraine patients presented values of much reduced DAO activity, and 46% of reduced activity. 95% of migraine patients experienced other symptoms related to histamine intolerance. The average value obtained for DAO activity is lower in the migraine group, with a significant difference (p=0.001).
The results confirm the scope of the research and show that DAO activity is significantly lower in migraine patients compared to controls.
Role of histamine and diamine oxidase enzyme in Multiple Sclerosis.
- Farokhi, M. Etemadifar, A. Rezaei, A. Amani, H. Jahanbani
Multiple Sclerosis and related disorders, November 2014, Volume 3, Issue 6, Page 746