What is DAO deficiency
DAO deficiency is an alteration in the metabolism of food histamine that occurs when there is little activity of the enzyme diamine oxidase (DAO). The DAO is the main enzyme in the metabolism of exogenous histamine and begins its functional activity in the intestine.
When exists a disproportion between the histamine swallowed or released by the cells that store it in the body, and the ability to metabolize it, there is the accumulation of histamine in plasma and the appearance of adverse effects.
A deficit in the metabolic activity of diamine oxidase can be due to genetic, pharmacological and pathological factors.
main symptoms in DAO deficiency
Migraine, fibromyalgia, irritable bowel syndrome (IBS) and the attention deficit-hyperactivity disorder (ADHD) are the symptoms with higher prevalences in the world population caused by DAO deficiency.
Actuality about DAO deficiency
News in media and press releases
According to a study the 90% of migraines can be treated with the enzyme DAO – Interview of RTVE to Juanjo Duelo, CEO of DR Healthcare
Clinical evidence and scientific publications
Activities and events on DAO deficiency
Conference “Migraine and other functional symptoms of DAO Deficiency” in the Official College of Pharmaceutits of Tarragona