{"id":10969,"date":"2011-01-20T09:46:03","date_gmt":"2011-01-20T09:46:03","guid":{"rendered":"https:\/\/new.dr-healthcare.com\/2011\/01\/20\/histamine-intolerance-lack-of-reproducibility-of-single-symptoms-by-oral-provocation-with-histamine-a-randomised-double-blind-placebo-controlled-cross-over-study\/"},"modified":"2023-02-17T18:06:55","modified_gmt":"2023-02-17T18:06:55","slug":"histamine-intolerance-lack-of-reproducibility-of-single-symptoms-by-oral-provocation-with-histamine-a-randomised-double-blind-placebo-controlled-cross-over-study","status":"publish","type":"post","link":"https:\/\/dr-healthcare.com\/en\/2011\/01\/20\/histamine-intolerance-lack-of-reproducibility-of-single-symptoms-by-oral-provocation-with-histamine-a-randomised-double-blind-placebo-controlled-cross-over-study\/","title":{"rendered":"Histamine intolerance: lack of reproducibility of single symptoms by oral provocation with histamine: a randomised, double-blind, placebo-controlled cross-over study."},"content":{"rendered":"

download pdf<\/a><\/p>\n

Wien Klin Wochenschr.<\/a><\/span>\u00a02011 Jan;123(1-2):15-20. doi: 10.1007\/s00508-010-1506-y. Epub 2010 Dec 20.<\/div>\n
Komericki P<\/a>1<\/sup>,\u00a0Klein G<\/a>,\u00a0Reider N<\/a>,\u00a0Hawranek T<\/a>,\u00a0Strimitzer T<\/a>,\u00a0Lang R<\/a>,\u00a0Kranzelbinder B<\/a>,\u00a0Aberer W<\/a>.<\/div>\n
\n

Author information<\/span><\/h3>\n
\n
\n
1<\/dt>\n
Department of Environmental Dermatology and Venereology, Medical University of Graz, Graz, Austria. peter.komericki@medunigraz.at<\/dd>\n<\/dl>\n<\/div>\n<\/div>\n
\n

Abstract<\/h3>\n
\n

OBJECTIVES:<\/h4>\n

The term\u00a0histamine<\/span>\u00a0intolerance<\/span>\u00a0stands for a range of symptoms involving various effector organs after the consumption of\u00a0histamine<\/span>-rich food. Our intention was to objectify and quantify\u00a0histamine<\/span>-associated symptoms and to analyse whether oral administration of the\u00a0histamine<\/span>-degrading enzyme diamine oxidase (DAO) caused a reduction of symptoms.<\/p>\n

PATIENTS AND METHODS:<\/h4>\n

Four Austrian centres participated. Patients suspected to be\u00a0histamine<\/span>\u00a0intolerant were recruited. The first step consisted in the open oral provocation of these patients with 75 mg of liquid\u00a0histamine<\/span>. Patients who developed symptoms were tested in a randomised double blind crossover provocation protocol using\u00a0histamine<\/span>-containing and\u00a0histamine<\/span>-free tea in combination with DAO capsules or placebo. Main and secondary symptoms (strongest and weaker symptoms based on a ten-point scale) were defined, the grand total of all symptoms of the individual provocation steps was determined and changes in symptoms after administration of DAO were measured.<\/p>\n

RESULTS:<\/h4>\n

Thirty nine patients reacted to the open\u00a0histamine<\/span>\u00a0provocation and were enrolled in the blinded part. Here, both the main and secondary symptoms were not reproducible. Subjects reacted sometimes unexpectedly and randomly. Regarding the total symptom scores, the differences between the three treatment groups were statistically significant. The intake of DAO demonstrated a statistically significant reduction of\u00a0histamine<\/span>-associated symptoms compared to placebo (P = 0.014).<\/p>\n

CONCLUSIONS:<\/h4>\n

Oral provocation with 75 mg of liquid\u00a0histamine<\/span>\u00a0failed to reproduce\u00a0histamine<\/span>-associated single symptoms in many patients. One may suggest that\u00a0histamine<\/span>-intolerant subjects reacted with different organs on different occasions. As a consequence, reproducibility of single symptoms alone may not be appropriate to diagnose\u00a0histamine<\/span>–intolerance<\/span>\u00a0whereas a global symptom score could be more appropriate. The fact, that the intake of DAO capsules compared to placebo led to a statistically significant reduction of total symptom scores, may indirectly point in the same direction.<\/p>\n<\/div>\n<\/div>\n

\n
\n
\n
PMID:<\/dt>\n
21165702<\/dd>\n
DOI:<\/dt>\n
10.1007\/s00508-010-1506-y<\/a><\/dd>\n<\/dl>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

The term\u00a0histamine\u00a0intolerance\u00a0stands for a range of symptoms involving various effector organs after the consumption of\u00a0histamine-rich food. Our intention was to objectify and quantify\u00a0histamine-associated symptoms and to analyse whether oral administration of the\u00a0histamine-degrading enzyme diamine oxidase (DAO) caused a reduction of symptoms.<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[],"tags":[],"yoast_head":"\nHistamine intolerance: lack of reproducibility of single symptoms by oral provocation with histamine: a randomised, double-blind, placebo-controlled cross-over study. –<\/title>\n<meta name=\"description\" content=\"The term histamine intolerance stands for a range of symptoms involving various effector organs after the consumption of histamine-rich food.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dr-healthcare.com\/en\/2011\/01\/20\/histamine-intolerance-lack-of-reproducibility-of-single-symptoms-by-oral-provocation-with-histamine-a-randomised-double-blind-placebo-controlled-cross-over-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Histamine intolerance: lack of reproducibility of single symptoms by oral provocation with histamine: a randomised, double-blind, placebo-controlled cross-over study.\" \/>\n<meta property=\"og:description\" content=\"The term histamine intolerance stands for a range of symptoms involving various effector organs after the consumption of histamine-rich food.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dr-healthcare.com\/en\/2011\/01\/20\/histamine-intolerance-lack-of-reproducibility-of-single-symptoms-by-oral-provocation-with-histamine-a-randomised-double-blind-placebo-controlled-cross-over-study\/\" \/>\n<meta property=\"og:site_name\" content=\"DR Healthcare - 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