{"id":11003,"date":"2006-05-20T08:34:31","date_gmt":"2006-05-20T08:34:31","guid":{"rendered":"https:\/\/new.dr-healthcare.com\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/"},"modified":"2023-02-17T18:09:37","modified_gmt":"2023-02-17T18:09:37","slug":"evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2","status":"publish","type":"post","link":"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/","title":{"rendered":"Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema"},"content":{"rendered":"

download pdf<\/a><\/p>\n

J Allergy Clin Immunol.<\/a><\/span>\u00a02006 May;117(5):1106-12. Epub 2006 Feb 8.<\/div>\n
Maintz L<\/a>1<\/sup>,\u00a0Benfadal S<\/a>,\u00a0Allam JP<\/a>,\u00a0Hagemann T<\/a>,\u00a0Fimmers R<\/a>,\u00a0Novak N<\/a>.<\/div>\n
\n

Author information<\/span><\/h3>\n
\n
\n
1<\/dt>\n
Department of Dermatology, University of Bonn, Germany.<\/dd>\n<\/dl>\n<\/div>\n<\/div>\n
\n

Abstract<\/h3>\n
\n

BACKGROUND:<\/h4>\n

A diminished histamine degradation based on a reduced diaminoxidase activity is suspected as a reason for non-IgE-mediated food intolerance caused by histamine. Atopic eczema (AE) is often complicated by relapses triggered by IgE-mediated allergy to different kinds of food. However, in a subgroup of patients with AE, allergy testing proves negative, although these patients report a coherence of food intake and worsening of AE and describe symptoms that are very similar to histamine intolerance (HIT).<\/p>\n

OBJECTIVES:<\/h4>\n

It was the aim of our study to evaluate symptoms of HIT in combination with diaminoxidase levels in a total of 360 individuals consisting of patients with AE (n = 162) in comparison with patients with HIT (n = 124) without AE and healthy control volunteers (n = 85).<\/p>\n

METHODS:<\/h4>\n

Histamine plasma level was determined with an ELISA and diaminoxidase serum activity with the help of radio extraction assays using [3H]-labeled putrescine-dihydrochloride as a substrate. Detailed clinical evaluations of characteristic features of AE and HIT were performed.<\/p>\n

RESULTS:<\/h4>\n

Reduced diaminoxidase serum levels leading to occurrence of HIT symptoms like chronic headache, dysmenorrhea, flushing, gastrointestinal symptoms, and intolerance of histamine-rich food and alcohol were significantly more common in patients with AE than in controls. Reduction of both symptoms of HIT and Severity Scoring of Atopic Dermatitis could be achieved by a histamine-free diet in the subgroup of patients with AE and low diaminoxidase serum levels.<\/p>\n

CONCLUSION:<\/h4>\n

Higher histamine plasma levels combined with a reduced histamine degradation capacity might influence the clinical course of a subgroup of patients with AE.<\/p>\n

CLINICAL IMPLICATIONS:<\/h4>\n

As HIT emerges in a subgroup of patients with AE, a detailed anamnestic evaluation of food intolerance and HIT symptoms complemented by an allergological screening for food allergy, a diet diary, and, in confirmed suspicion of HIT, measurement of diaminoxidase activity and a histamine-free diet should be undertaken.<\/p>\n<\/div>\n<\/div>\n

\n
\n
\n
PMID:<\/dt>\n
16675339<\/dd>\n
DOI:<\/dt>\n
10.1016\/j.jaci.2005.11.041<\/a><\/dd>\n<\/dl>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Reduced diaminoxidase serum levels leading to occurrence of HIT symptoms like chronic headache, dysmenorrhea, flushing, gastrointestinal symptoms, and intolerance of histamine-rich food and alcohol were significantly more common in patients with AE than in controls.<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[],"tags":[],"yoast_head":"\nEvidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema –<\/title>\n<meta name=\"description\" content=\"Reduced diaminoxidase serum levels leading to occurrence of HIT symptoms like chronic headache, dysmenorrhea, flushing\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema\" \/>\n<meta property=\"og:description\" content=\"Reduced diaminoxidase serum levels leading to occurrence of HIT symptoms like chronic headache, dysmenorrhea, flushing\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/\" \/>\n<meta property=\"og:site_name\" content=\"DR Healthcare - Innovating in DAO deficiency through Medical Nutrition\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/deficitdao\" \/>\n<meta property=\"article:published_time\" content=\"2006-05-20T08:34:31+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-02-17T18:09:37+00:00\" \/>\n<meta name=\"author\" content=\"dr-healthcare\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"dr-healthcare\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/\"},\"author\":{\"name\":\"dr-healthcare\",\"@id\":\"https:\/\/dr-healthcare.com\/en\/#\/schema\/person\/5bec411e7c0f45d6a7359fe68338b3e5\"},\"headline\":\"Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema\",\"datePublished\":\"2006-05-20T08:34:31+00:00\",\"dateModified\":\"2023-02-17T18:09:37+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/\"},\"wordCount\":350,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/dr-healthcare.com\/en\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/\",\"url\":\"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/\",\"name\":\"Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema –\",\"isPartOf\":{\"@id\":\"https:\/\/dr-healthcare.com\/en\/#website\"},\"datePublished\":\"2006-05-20T08:34:31+00:00\",\"dateModified\":\"2023-02-17T18:09:37+00:00\",\"description\":\"Reduced diaminoxidase serum levels leading to occurrence of HIT symptoms like chronic headache, dysmenorrhea, flushing\",\"breadcrumb\":{\"@id\":\"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\/\/dr-healthcare.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/dr-healthcare.com\/en\/#website\",\"url\":\"https:\/\/dr-healthcare.com\/en\/\",\"name\":\"DR-Healthcare - Innovating in DAO Deficiency through Medical Nutrition\",\"description\":\"Biomedical company specialist in Medical Food and Medical Nutrition for the prevention and treatment of DAO Deficiency metabolic disorders\",\"publisher\":{\"@id\":\"https:\/\/dr-healthcare.com\/en\/#organization\"},\"alternateName\":\"DR Healthcare\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/dr-healthcare.com\/en\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/dr-healthcare.com\/en\/#organization\",\"name\":\"DR Healthcare\",\"alternateName\":\"DRHC\",\"url\":\"https:\/\/dr-healthcare.com\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/dr-healthcare.com\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/dr-healthcare.com\/wp-content\/uploads\/2022\/06\/Logo-DRH-22-212x100-fondo-trans.png\",\"contentUrl\":\"https:\/\/dr-healthcare.com\/wp-content\/uploads\/2022\/06\/Logo-DRH-22-212x100-fondo-trans.png\",\"width\":212,\"height\":100,\"caption\":\"DR Healthcare\"},\"image\":{\"@id\":\"https:\/\/dr-healthcare.com\/en\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/deficitdao\",\"https:\/\/www.instagram.com\/dr_healthcare\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/dr-healthcare.com\/en\/#\/schema\/person\/5bec411e7c0f45d6a7359fe68338b3e5\",\"name\":\"dr-healthcare\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/dr-healthcare.com\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/3e5633663387c8cc58b4bda569e4f397?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/3e5633663387c8cc58b4bda569e4f397?s=96&d=mm&r=g\",\"caption\":\"dr-healthcare\"},\"url\":\"https:\/\/dr-healthcare.com\/en\/author\/dr-healthcare\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema –","description":"Reduced diaminoxidase serum levels leading to occurrence of HIT symptoms like chronic headache, dysmenorrhea, flushing","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/","og_locale":"en_US","og_type":"article","og_title":"Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema","og_description":"Reduced diaminoxidase serum levels leading to occurrence of HIT symptoms like chronic headache, dysmenorrhea, flushing","og_url":"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/","og_site_name":"DR Healthcare - Innovating in DAO deficiency through Medical Nutrition","article_publisher":"https:\/\/www.facebook.com\/deficitdao","article_published_time":"2006-05-20T08:34:31+00:00","article_modified_time":"2023-02-17T18:09:37+00:00","author":"dr-healthcare","twitter_card":"summary_large_image","twitter_misc":{"Written by":"dr-healthcare","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/#article","isPartOf":{"@id":"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/"},"author":{"name":"dr-healthcare","@id":"https:\/\/dr-healthcare.com\/en\/#\/schema\/person\/5bec411e7c0f45d6a7359fe68338b3e5"},"headline":"Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema","datePublished":"2006-05-20T08:34:31+00:00","dateModified":"2023-02-17T18:09:37+00:00","mainEntityOfPage":{"@id":"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/"},"wordCount":350,"commentCount":0,"publisher":{"@id":"https:\/\/dr-healthcare.com\/en\/#organization"},"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/","url":"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/","name":"Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema –","isPartOf":{"@id":"https:\/\/dr-healthcare.com\/en\/#website"},"datePublished":"2006-05-20T08:34:31+00:00","dateModified":"2023-02-17T18:09:37+00:00","description":"Reduced diaminoxidase serum levels leading to occurrence of HIT symptoms like chronic headache, dysmenorrhea, flushing","breadcrumb":{"@id":"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/dr-healthcare.com\/en\/2006\/05\/20\/evidence-for-a-reduced-histamine-degradation-capacity-in-a-subgroup-of-patients-with-atopic-eczema-2\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/dr-healthcare.com\/en\/"},{"@type":"ListItem","position":2,"name":"Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema"}]},{"@type":"WebSite","@id":"https:\/\/dr-healthcare.com\/en\/#website","url":"https:\/\/dr-healthcare.com\/en\/","name":"DR-Healthcare - Innovating in DAO Deficiency through Medical Nutrition","description":"Biomedical company specialist in Medical Food and Medical Nutrition for the prevention and treatment of DAO Deficiency metabolic disorders","publisher":{"@id":"https:\/\/dr-healthcare.com\/en\/#organization"},"alternateName":"DR Healthcare","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/dr-healthcare.com\/en\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/dr-healthcare.com\/en\/#organization","name":"DR Healthcare","alternateName":"DRHC","url":"https:\/\/dr-healthcare.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/dr-healthcare.com\/en\/#\/schema\/logo\/image\/","url":"https:\/\/dr-healthcare.com\/wp-content\/uploads\/2022\/06\/Logo-DRH-22-212x100-fondo-trans.png","contentUrl":"https:\/\/dr-healthcare.com\/wp-content\/uploads\/2022\/06\/Logo-DRH-22-212x100-fondo-trans.png","width":212,"height":100,"caption":"DR Healthcare"},"image":{"@id":"https:\/\/dr-healthcare.com\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/deficitdao","https:\/\/www.instagram.com\/dr_healthcare\/"]},{"@type":"Person","@id":"https:\/\/dr-healthcare.com\/en\/#\/schema\/person\/5bec411e7c0f45d6a7359fe68338b3e5","name":"dr-healthcare","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/dr-healthcare.com\/en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/3e5633663387c8cc58b4bda569e4f397?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/3e5633663387c8cc58b4bda569e4f397?s=96&d=mm&r=g","caption":"dr-healthcare"},"url":"https:\/\/dr-healthcare.com\/en\/author\/dr-healthcare\/"}]}},"_links":{"self":[{"href":"https:\/\/dr-healthcare.com\/en\/wp-json\/wp\/v2\/posts\/11003"}],"collection":[{"href":"https:\/\/dr-healthcare.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dr-healthcare.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dr-healthcare.com\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/dr-healthcare.com\/en\/wp-json\/wp\/v2\/comments?post=11003"}],"version-history":[{"count":0,"href":"https:\/\/dr-healthcare.com\/en\/wp-json\/wp\/v2\/posts\/11003\/revisions"}],"wp:attachment":[{"href":"https:\/\/dr-healthcare.com\/en\/wp-json\/wp\/v2\/media?parent=11003"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dr-healthcare.com\/en\/wp-json\/wp\/v2\/categories?post=11003"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dr-healthcare.com\/en\/wp-json\/wp\/v2\/tags?post=11003"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}