When histamine-rich foods aren’t well tolerated, or histamine isn’t naturally broken down, related discomfort can extend beyond diet, impacting your confidence, your plans, and your daily wellbeing.
DAO enzyme food supplements by DR Healthcare are designed to accompany your dietary routine with supplement solutions based on selected ingredients naturally containing Diamine Oxidase (DAO), an enzyme involved in the metabolism of histamine present in food.
Many people describe a similar pattern in the way they think about food choices and dietary habits.
- Uncertainty about which foods to choose
- Interest in learning more about food composition and dietary habits
- Considering food choices when eating out, travelling or sharing meals
- Seeking practical information to support informed dietary decisions
Individual experiences may vary.
A different way to approach your diet
- A greater understanding of dietary choices
- A better understanding of the role dietary histamine may play in food
- A more informed approach to your daily food routine
DAO: part of the natural process
Diamine Oxidase (DAO) is an enzyme naturally present in the body which is involved in the metabolism of histamine from food in the small intestine.
Histamine in food: a widely shared, often under-recognised experience
Histamine is a biologically active compound involved in normal physiological processes such as immune response, gastric acid secretion, and neurotransmission. While the histamine produced within the body is tightly regulated, histamine is also naturally present in a wide range of foods, representing an often under-recognised source of exposure.
How is dietary histamine managed in the body?
Histamine is naturally metabolised in the small intestine by the Diamine Oxidase (DAO) enzyme. Diet and individual factors may influence how efficiently this process takes place.1
Unlike endogenous histamine, food-derived histamine has no physiological function. Its levels vary widely depending on food type, processing, storage, and fermentation. As a result, dietary intake can significantly increase histamine exposure.
Found across all food cultures and regions
Aged cheeses rooted in European tradition, fermented soy products in Asian cuisine, cured meats in Mediterranean diets, fish sauces across Southeast Asia all contribute to dietary histamine. Wine, beer and pickled or fermented vegetables found worldwide further add to overall intake. Together, these foods make histamine-rich foods a global constant rather than a regional exception.
Factors that influence dietary histamine levels
- Food type and natural histamine content
- Degree of fermentation or ageing
- Storage conditions and food freshness
- Food preparation and processing methods
- Individual biological variability
- Frequency and quantity of consumption
Foods commonly associated with higher histamine content
- Fermented products (kimchi, sauerkraut, miso, kefir)
- Aged and cured cheeses
- Processed and cured meats
- Certain fish and seafood products
- Alcoholic beverages (wine, beer, champagne)
- Certain fruits and vegetables
- Vinegar-based products and condiments
Millions of people across different regions, dietary habits, and lifestyles may be affected by dietary histamine, yet many do not recognise the connection.
Why choose DAO food supplements by DR Healthcare?
The value of a DAO enzyme food supplement goes beyond a single number. Quality, consistency and delivery to your body matter.
Verified enzyme activity
DAO activity is directly measured using validated analytical methods, rather than estimated. Histamine degradation assays are conducted with independently verified third parties to ensure consistent and reliable enzymatic activity.
Batch-to-batch consistency
Each batch is controlled to ensure consistent enzymatic levels and reproducibility, delivering reliable quality you can trust.
Stability over time
Formulated to maintain enzymatic activity throughout shelf life, ensuring performance over time.
Targeted intestinal release
Gastro-resistant technology protects the enzyme under acidic stomach conditions, ensuring DAO is released where it is needed, in the small intestine.
High quality standards
Developed following European quality frameworks, safety controls and reproducibility between batches.
18+ years of DAO science
DR Healthcare brings over 18 years of expertise in DAO enzyme supplementation reflecting a focused, long-term commitment to reliable formulation and scientific rigour.
Verified enzyme activity. Proven stability. Designed precision.
1. Comas-Basté, O., Sánchez-Pérez, S., Veciana-Nogués, M. T., Latorre-Moratalla, M., & Vidal-Carou, M. C. (2020).Histamine intolerance: The current state of the art. Biomolecules, 10(8), 1181.