We are a Biomedical Company specialized in Medical Nutrition,

founded in 2007 in Barcelona (Spain), we develop activities of research, development, innovation, marketing and licensing-out of new nutraceuticals and functional foods.

Our great value is the investigation and we firmly believe in the alliance between “Company-University”, developing our activities in two R&D&i centers

From our production plant we offer our nutraceuticals products in different gastro-resistant formats (tablets, pellets, micropellets, capsules, microcapsules and nanocapsules), facilitating the adaptation to the current regulations of each market and their marketing on an international scale.

We also develop In Vitro molecular diagnostic kits


DR Healthcare stands out for being a leader in production of Diamine Oxidase,

what allows us to offer tailored solutions for use in the veterinary, animal health and food sectors.

Our solutions based on Diamine Oxidase are adapted to new laws and standards in food control, which stipulate the control of the levels of histamine in order to avoid the risk of intoxication due to the consumption of high amounts of this biogenic amine present in food.

diamino oxidasa para el sector veterinario

veterinary and animal health sectors

Veterinary solutions based on diamine oxidase to prevent the histaminosis in domestic animals, livestock and aquaculture. Their health is that of all being vital to avoid the pathophysiological effects that trigger high levels of histamine.

diamino oxidasa para industria alimentaria

food industry sector

FAO and WHO and countries around the world have implemented regulations that include the analysis of those foods that may contain high levels of histamine and measures to prevent their production through a correct preservation, processing and distribution.

specialists in DAO deficiency

DAO deficiency is an alteration in the metabolism of food histamine that occurs when there is little activity of the enzyme diamine oxidase (DAO). The DAO is the main enzyme in the metabolism of exogenous histamine and begins its functional activity in the intestine.

When exists a disproportion between the histamine swallowed or released by the cells that store it in the body, and the ability to metabolize it, there is the accumulation of histamine in plasma and the appearance of adverse effects.

A deficit in the metabolic activity of diamine oxidase can be due to genetic, pharmacological and pathological factors.

main symptoms in DAO DEFICIENCY

Migraine, fibromyalgia, irritable bowel syndrome (IBS) and the attention deficit-hyperactivity disorder (ADHD) are the symptoms with higher prevalences in the world population caused by DAO deficiency.


millions of people affected by ADHD

% of the population with ADHD is also affected of DAO deficiency

millions of people affected by migraine

% of the population with migraine is also affected of DAO deficiency

millions people affected by fibromyalgia

% of the population with fibromyalgia is also affected of DAO deficiency

millions of people affected by Irritable Bowel Syndrome

% of the population with Irritable Bowel Syndrome is also affected of DAO deficiency

Actuality about DAO deficiency

News in media and press releases

Migraines seem to be caused most likely by histamine than by ethanol – Eur J Neurol

The past 20 May was published in the European Journal of Neurology an article in which the doctors Wolfgang J Schnedl and Robert Queissner stated that there was apparently a greater relationship between the cause of migraines and histamine rather than with ethanol present in alcoholic beverages. In the letter to the editor that have published both doctors, reflect on...

Scientific and clinical evidence

Migraines appear more likely to be caused by histamine rather than ethanol

Migraines appear more likely to be caused by histamine rather than ethanol. Dowload the pdf Schnedl WJ1, Queissner R2. Eur J Neurol. 2019 May 20. doi: 10.1111/ene.14003. Author information 1General Internal Medicine Practice, Dr. Theodor Körnerstrasse 19b, 8600, Bruck, Austria.2Department of Psychiatry and Psychotherapeutic Medicine,...

Activities and events on DAO deficiency


Next Monday 17 June (2019), will take place from 14.00 to 16.00 hours in the University Rovira i Virgili (Edifici N5 Sustainable Chemistry, Assembly Hall.Marcel.li Sunday, 2-4-6, Sescelades Campus 43007-Tarragona, Spain) the training activity “DAO deficiency and the role of the pharmacist in the diagnosis and treatment” (language: Spanish). This training is organized...


Are underestimated the amounts of biogenic amines in diets low in histamine ?

  Diets low in histamine are currently used to reduce symptoms of intolerance to histamine, a disorder in the homeostasis of this molecule that increases its blood levels, due mainly to the reduction of the activity of the diamine oxidase (DAO) enzyme. In fact, these diets low in histamine exclude foods, many of them of plant origin, that patients associate with the...
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DR HEALTHCARE ESPAÑA, S.L. (Barcelona, Spain)