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DR HEALTHCARE


We are a Biomedical Company specialized in Medical Nutrition,

founded in 2007 in Barcelona (Spain), we develop activities of research, development, innovation, marketing and licensing-out of new nutraceuticals and functional foods.

Our great value is the investigation and we firmly believe in the alliance between “Company-University”, developing our activities in two R&D&i centers

From our production plant we offer our nutraceuticals products in different gastro-resistant formats (tablets, pellets, micropellets, capsules, microcapsules and nanocapsules), facilitating the adaptation to the current regulations of each market and their marketing on an international scale.

We also develop In Vitro molecular diagnostic kits

DAO LEADER PRODUCER


DR Healthcare stands out for being a leader in production of Diamine Oxidase,

what allows us to offer tailored solutions for use in the veterinary, animal health and food sectors.

Our solutions based on Diamine Oxidase are adapted to new laws and standards in food control, which stipulate the control of the levels of histamine in order to avoid the risk of intoxication due to the consumption of high amounts of this biogenic amine present in food.

diamino oxidasa para el sector veterinario enzima dao enzima diamino oxidasa diamino oxidasa histamina intolerancia a la histamina histaminosis escombroidosis déficit de DAO histamina en los alimentos alimentos ricos en histamia bloqueo de la histamina degradación de la histamina metabolismo de la histamina metabolización de la histamina niveles altos de histamina migraña dolor de cabeza cefalea acufenos tinnitus estreñimiento diarrea síndrome de intestino irritable síndrome de colon irritable distensión abdominal flatulencia hinchazón estomacal reflujo estomacal acidez estomacal nausea vómito dolor de estómago mareo vómito cíclico gastritis dolor muscular fibromialgia contracturas fatiga crónica dermatitis piel atópica piel seca atopia dr healthcare daofood migrasin daokids fibrodao probidao eficaps irritable bowel stomach ache gastritis constipation diarrhea bloating flatulence heatburn vomiting syndrome nausea dizziness dermatitis atopic skin dry skin atopie fibromyalgia muscle pain chronic fatigue contracture Headache migraine tinnitus DAO dao enzyme diamino oxidase enzyme diamino oxidase histamine histamine intolerance histaminosis debris DAO deficit histamine in food foods rich in histamia histamine block histamine degradation histamine metabolism histamine metabolization high histamine levels dr healthcare daofood migrasin daokids fibrodao probidao eficaps Verstopfung Durchfall Reizdarmsyndrom Reizdarmsyndrom Aufblähung Blähungen Magenschwellung Magen-Reflux Sodbrennen Übelkeit Erbrechen Bauchschmerzen Schwindel Abführmittel zyklisches Erbrechen Magenschleimhautentzündung gastritis Dermatitis atopische Haut trockene haut atopy Muskelschmerzen Fibromyalgie Kontrakturen chronische Müdigkeit Migräne Kopfschmerzen hemikranie tinnitus tinnitus dao Dao-Enzym Diaminooxidase-Enzym Diaminooxidase Histamin Histamin-Unverträglichkeit Histaminose Trümmer DAO-Defizit Histamin in Lebensmitteln Lebensmittel reich an Histamie Histamin-Block Histamin-Abbau Histamin-Stoffwechsel Histamin-Metabolisierung hoher Histaminspiegel dr healthcare daofood migrasin daokids fibrodao probidao eficaps dr healthcare daofood migrasin daokids fibrodao probidao constipation la diarrhée syndrome du côlon irritable syndrome du côlon irritable ballonnements flatulences gonflement de l'estomac reflux d'estomac brûlures d'estomac nausée vomir mal au ventre vertige vomissements cycliques gastrite dermatite peau atopique peau sèche atopie douleur musculaire fibromyalgie contractures fatigue chronique migraine mal de tête mal de tête acouphènes acouphènes dao dao enzyme enzyme diamino oxydase diamino oxydase l'histamine intolérance à l'histamine histaminose débris Déficit DAO histamine dans les aliments aliments riches en histamia bloc d'histamine dégradation de l'histamine métabolisme de l'histamine métabolisation de l'histamine niveaux élevés d'histamine eficaps costipazione diarrea sindrome dell'intestino irritabile sindrome dell'intestino irritabile distensione addominale flatulenza gonfiore allo stomaco reflusso di stomaco bruciore di stomaco nausea vomito mal di stomaco vertigini vomito ciclico gastrite douleur musculaire fibromyalgie contractures fatigue chronique dermatite pelle atopique Pelle Secca atopie dao enzima enzima diamino ossidasi diamino ossidasi istamina intolleranza all'istamina histaminosis scromboid Deficit DAO istamina nel cibo cibi ricchi di istamia blocco di istamina degradazione dell'istamina metabolismo dell'istamina metabolizzazione dell'istamina alti livelli di istamina dao dr healthcare daofood migrasin daokids fibrodao probidao eficaps

veterinary and animal health sectors

Veterinary solutions based on diamine oxidase to prevent the histaminosis in domestic animals, livestock and aquaculture. Their health is that of all being vital to avoid the pathophysiological effects that trigger high levels of histamine.

diamino oxidasa para industria alimentaria enzima dao enzima diamino oxidasa diamino oxidasa histamina intolerancia a la histamina histaminosis escombroidosis déficit de DAO histamina en los alimentos alimentos ricos en histamia bloqueo de la histamina degradación de la histamina metabolismo de la histamina metabolización de la histamina niveles altos de histamina migraña dolor de cabeza cefalea acufenos tinnitus estreñimiento diarrea síndrome de intestino irritable síndrome de colon irritable distensión abdominal flatulencia hinchazón estomacal reflujo estomacal acidez estomacal nausea vómito dolor de estómago mareo vómito cíclico gastritis dolor muscular fibromialgia contracturas fatiga crónica dermatitis piel atópica piel seca atopia dr healthcare daofood migrasin daokids fibrodao probidao eficaps irritable bowel stomach ache gastritis constipation diarrhea bloating flatulence heatburn vomiting syndrome nausea dizziness dermatitis atopic skin dry skin atopie fibromyalgia muscle pain chronic fatigue contracture Headache migraine tinnitus DAO dao enzyme diamino oxidase enzyme diamino oxidase histamine histamine intolerance histaminosis debris DAO deficit histamine in food foods rich in histamia histamine block histamine degradation histamine metabolism histamine metabolization high histamine levels dr healthcare daofood migrasin daokids fibrodao probidao eficaps Verstopfung Durchfall Reizdarmsyndrom Reizdarmsyndrom Aufblähung Blähungen Magenschwellung Magen-Reflux Sodbrennen Übelkeit Erbrechen Bauchschmerzen Schwindel Abführmittel zyklisches Erbrechen Magenschleimhautentzündung gastritis Dermatitis atopische Haut trockene haut atopy Muskelschmerzen Fibromyalgie Kontrakturen chronische Müdigkeit Migräne Kopfschmerzen hemikranie tinnitus tinnitus dao Dao-Enzym Diaminooxidase-Enzym Diaminooxidase Histamin Histamin-Unverträglichkeit Histaminose Trümmer DAO-Defizit Histamin in Lebensmitteln Lebensmittel reich an Histamie Histamin-Block Histamin-Abbau Histamin-Stoffwechsel Histamin-Metabolisierung hoher Histaminspiegel dr healthcare daofood migrasin daokids fibrodao probidao eficaps dr healthcare daofood migrasin daokids fibrodao probidao constipation la diarrhée syndrome du côlon irritable syndrome du côlon irritable ballonnements flatulences gonflement de l'estomac reflux d'estomac brûlures d'estomac nausée vomir mal au ventre vertige vomissements cycliques gastrite dermatite peau atopique peau sèche atopie douleur musculaire fibromyalgie contractures fatigue chronique migraine mal de tête mal de tête acouphènes acouphènes dao dao enzyme enzyme diamino oxydase diamino oxydase l'histamine intolérance à l'histamine histaminose débris Déficit DAO histamine dans les aliments aliments riches en histamia bloc d'histamine dégradation de l'histamine métabolisme de l'histamine métabolisation de l'histamine niveaux élevés d'histamine eficaps costipazione diarrea sindrome dell'intestino irritabile sindrome dell'intestino irritabile distensione addominale flatulenza gonfiore allo stomaco reflusso di stomaco bruciore di stomaco nausea vomito mal di stomaco vertigini vomito ciclico gastrite douleur musculaire fibromyalgie contractures fatigue chronique dermatite pelle atopique Pelle Secca atopie dao enzima enzima diamino ossidasi diamino ossidasi istamina intolleranza all'istamina histaminosis scromboid Deficit DAO istamina nel cibo cibi ricchi di istamia blocco di istamina degradazione dell'istamina metabolismo dell'istamina metabolizzazione dell'istamina alti livelli di istamina dao dr healthcare daofood migrasin daokids fibrodao probidao eficaps

food industry sector

FAO and WHO and countries around the world have implemented regulations that include the analysis of those foods that may contain high levels of histamine and measures to prevent their production through a correct preservation, processing and distribution.

specialists in DAO deficiency

DAO deficiency is an alteration in the metabolism of food histamine that occurs when there is little activity of the enzyme diamine oxidase (DAO). The DAO is the main enzyme in the metabolism of exogenous histamine and begins its functional activity in the intestine.

When exists a disproportion between the histamine swallowed or released by the cells that store it in the body, and the ability to metabolize it, there is the accumulation of histamine in plasma and the appearance of adverse effects.

A deficit in the metabolic activity of diamine oxidase can be due to genetic, pharmacological and pathological factors.

main symptoms in DAO DEFICIENCY

Migraine, fibromyalgia, irritable bowel syndrome (IBS) and the attention deficit-hyperactivity disorder (ADHD) are the symptoms with higher prevalences in the world population caused by DAO deficiency.

388

millions of people affected by ADHD

72
% of the population with ADHD is also affected of DAO deficiency
1,050

millions of people affected by migraine

90
% of the population with migraine is also affected of DAO deficiency
124

millions people affected by fibromyalgia

78
% of the population with fibromyalgia is also affected of DAO deficiency
611

millions of people affected by Irritable Bowel Syndrome

67
% of the population with Irritable Bowel Syndrome is also affected of DAO deficiency

Actuality about DAO deficiency

News in media and press releases

Migraines seem to be caused most likely by histamine than by ethanol – Eur J Neurol

The past 20 May was published in the European Journal of Neurology an article in which the doctors Wolfgang J Schnedl and Robert Queissner stated that there was apparently a greater relationship between the cause of migraines and histamine rather than with ethanol present in alcoholic beverages. In the letter to the editor that have published both doctors, reflect on...

Scientific and clinical evidence

Association of Diamine oxidase (DAO) variants with the risk for migraine from North Indian population

Association of Diamine oxidase (DAO) variants with the risk for migraine from North Indian population Dowload pdf Sukhvinder Kaura,⁎, Arif Alib, Yaser Siahbalaeic, Uzair Ahmadc, Fazila Nargisc, A.K. Pandeyd, Balkirat Singhe a UGC-PDF, Gene Expression Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi, India b UGC-BSR-FF, Department of Biosciences,...

Activities and events on DAO deficiency

TRAINING ACTIVITY “DAO DEFICIENCY AND THE ROLE OF THE PHARMACIST IN THE DIAGNOSIS AND TREATMENT”

Next Monday 17 June (2019), will take place from 14.00 to 16.00 hours in the University Rovira i Virgili (Edifici N5 Sustainable Chemistry, Assembly Hall.Marcel.li Sunday, 2-4-6, Sescelades Campus 43007-Tarragona, Spain) the training activity “DAO deficiency and the role of the pharmacist in the diagnosis and treatment” (language: Spanish). This training is organized...

 Blog

Are underestimated the amounts of biogenic amines in diets low in histamine ?

  Diets low in histamine are currently used to reduce symptoms of intolerance to histamine, a disorder in the homeostasis of this molecule that increases its blood levels, due mainly to the reduction of the activity of the diamine oxidase (DAO) enzyme. In fact, these diets low in histamine exclude foods, many of them of plant origin, that patients associate with the...
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DR HEALTHCARE ESPAÑA, S.L. (Barcelona, Spain)