Diamine Oxidase as a triggering factor for migraine
Migraine is considered one of the most frequent secondary headaches. There are different ethiopathogenic theories, including the alimentary one. Histamine has a high presence in diet and the capacity to degrade it is different in each subject. It is determined by an enzyme called diamine oxidase (DAO). Our purpose is to measure the activity of this enzyme in patients suffering migraine.
Diamine Oxidase (DAO) deficiency as a predisposing factor for migraine
Migraine is considered as one of the most common secondary headaches. There are different etiopathogenic theories that include a food-related theory. Histamine is abundant in food and the ability to remove it varies from person to person. It is determined by an enzyme known as Diamine Oxidase (DAO).
Histamine intolerance: lack of reproducibility of single symptoms by oral provocation with histamine: a randomised, double-blind, placebo-controlled cross-over study.
The term histamine intolerance stands for a range of symptoms involving various effector organs after the consumption of histamine-rich food. Our intention was to objectify and quantify histamine-associated symptoms and to analyse whether oral administration of the histamine-degrading enzyme diamine oxidase (DAO) caused a reduction of symptoms.
Histamine and histamine intolerance
Histamine intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation. Histamine is a biogenic amine that occurs to various degrees in many foods. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity.
Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema
Reduced diaminoxidase serum levels leading to occurrence of HIT symptoms like chronic headache, dysmenorrhea, flushing, gastrointestinal symptoms, and intolerance of histamine-rich food and alcohol were significantly more common in patients with AE than in controls.