Activate your DAO with every meal

DAOfood®: dietary management of DAO deficiency / Histamine Intolerance

dermatology gastroenterology Products rheumatology

EAN 8437009482902


Dietary management of DAO deficiency / Histamine intolerance.

Available in pharmacies specialized in DAO deficiency. You can also buy it in online pharmacies and on amazon.

32,50 £ (VAT included)    FREE Shipping.

Receive it in 1 day with Prime.

    Diamine Oxidase (DAO) enzyme with high activity and bioavailability, ideal for  prolonged dietary management of DAO deficiency and its associated gastrointestinal, dermatological and muscular pathologies.

  Lightweight, portable and convenient: its tablets are small and easy to swallow and its dispenser bottle can be taken with you everywhere.

  Gastroresistant coated tablets allow the Diamine Oxidase enzyme not to be released in the stomach, but in a delayed form in the small intestine where it performs its action.

  Based on scientific and clinical evidence with the highest levels of quality in Medical Nutrition.


DAOfood® is a food for special medical purposes that is used for the dietary management of DAO Deficiency and/or Histamine Intolerance and its associated pathologies.

The Diamine Oxidase (DAO) contained in DAOfood® serves as a supplement to the enzyme found in the body, which oversees metabolizing histamine. Taking one tablet of DAOfood® before each meal increases the amount of DAO in the small bowel and therefore also boosts histamine degradation. This accelerates the processing of the histamine found in different foods in the digestive tract, which triggers the symptoms.

Histamine is an essential molecule, a transmitter that belongs to the so called group of biogenic amines and that is naturally present in many foods as well as inside our cells. Normally, the intake of histamine contained in food does not cause any problem, since it is quickly processed and metabolized by the Diamine Oxidase enzyme (DAO).

+ more info

DAO is the main enzyme for the metabolism of ingested histamine. lt is mainly located in the intestinal epithelium, where it absorbs and degrades the ingested histamine preventing it from passing into the bloodstream.

+ more info

lt refers to a deficiency in Diamine Oxidase (DAO) metabolization activity or when there is an imbalance between the ingested histamine and the enzyme capacity to metabolize it. As histamine has not been properly metabolized and degraded, it passes into the bloodstream triggering different symptoms. The most common reactions of DAO deficiency are migraine and headaches, although other symptoms may occur such as:

  • Digestive disorders such as bloated feeling, flatulence, constipation or diarrhoea.
  •  Pain and muscle contractures and osteopathic pain.
  •  Skin disorders, such as dry or atopic skin.

+ more info

Histamine is present in all foods a greater or lesser extent, whether plant or animal origin. Food undergoing a lengthy maturation or food stored for an extended period is particularly high in histamine and other biogenic amines also degraded by DAO enzyme.

These foods are, among others:

  • Raw or pasteurized milk and dairy products.
  • Citrus fruits, strawberries and banana.
  • Seafood, oily fish and fish sauces.
  • Raw cured sausage such as spiced sausage, chorizo or bacon.
  • Some vegetables such as tomatoes, spinach or aubergines.
  • Alcoholic drinks*, especially red and sparkling wine.

*Alcoholic drinks contain, to some extent, histamine or other biogenic amines, and furthermore, alcohol inhibits DAO activity impeding histamine degradation and metabolization.

+ more info

What does DAOfood® contain?

The DAOfood® dispenser bottle contains 60 gastroresistant tablets with controlled-release DAO enzye in the intestine that avoid the acid pH of the stomach.

  60 white/beige gastroresistant tablets with intestinal release DAO.


How should DAOfood® be used?

Take 1 tablet with some water 20 minutes before the main meals (3 times a day). The tablet should be swallowed whole without chewing, splitting or breaking them.

lmportant observations

DAOfood® does not a single food source. Alcohol and medicines may largely inhibit the action of the Diamine Oxidase enzyme (DAO). To be used only under the supervision of a qualified practitioner, who shall recommend the dosage according to the symptoms. Keep out of the reach of children. Store in a cool place. The tablets must be swallowed whole. It does not contain Histamine. Gluten free. Lactose free. Sugars free.


DAOfood® contains Diamine Oxidase (DAO), a thermolabile enzyme (sensitive to temperature), being advisable to keep it away from sources of heat. If consumed according to the dose recommended daily intake, does not require a special conservation, but if exceptionally consumes sporadically, being stored for long time, it is advisable to keep it in fridge.

Bulking agent: cellulose microcrystalline and hydroxypropylcellulose; pig kidney protein extract with 7% diamine oxidase (DAO); glazing agents: ethylcellulose, potato starch; stabilisers: sodium alginate and magnesium salts of fatty acids; medium chain triglycerides; glazing agent: hydroxypropylmethylcellulose; stabilisers: oleic acid and stearic acid.


Histamine is a molecule that is present in all foods in the daily diet, is also produced endogenously in the body, and is the mediator of many biological processes such as inflammation, allergies, gastric acid secretions, neuromodulation and regulation of immune function.

Under normal conditions, ingested histamine is broken down by the enzyme Diamine Oxidase (DAO) in the small intestine.

The problem

If the metabolic activity of the DAO enzyme is reduced (due to genetic, pharmacological and / or pathological factors), the ingested histamine cannot be degraded and passes through the intestinal mucosa to the circulation causing the appearance of gastrointestinal, cutaneous, neurological and muscular symptoms associated to DAO deficiency.

The solution

DAOfood® provides the exogenous DAO intake necessary to restore histamine metabolism. Proper DAO supplementation allows dietary management of your symptoms.


Foods for special medical purposes are intended to satisfy all or part of the dietary needs of patients whose ability to ingest, digest, absorb, metabolize or excrete normal foods or certain nutrients or metabolites thereof is limited, deficient or altered, or well that they need other clinically determined nutrients, whose dietary treatment cannot be carried out solely by modifying the normal diet, with other foods intended for a special diet, or by both (1). They are not drugs or food supplements.

The supply of DAO by mouth is a key strategy in the dietary management of migraine and other pathologies associated with the deficiency of this enzyme, since histamine is present to one degree or another in many foods in the usual diet, and for a In a patient with DAO deficiency, it is very difficult to suppress histamine foods since the histamine content is not normally specified by the manufacturers.

Foods for special medical uses that contain DAO prevent the systemic absorption of exogenous histamine, providing the patient with the necessary amount of DAO that complements the body’s own enzyme, strengthening the histamine degradation capacity of food locally in the small intestine and recovering the natural balance of histamine and DAO, thus reducing the symptoms of concomitant pathologies (2).

Bibliography and links

  1. Alimentos para usos médicos especiales. Disponible en: http://www.aecosan.msssi.gob.es/AECOSAN/web/seguridad_ alimentaria/subdetalle/alimentos_usos_medicos.htm
  2. Izquierdo-Casas J, Comas-Basté O, Latorre-Moratalla ML, Lorente-Gascón M, Duelo A, Soler-Singla L, et al. Diamine oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: a randomized double-blind trial. Clin Nutr. 2019; 38: 152-158.

DAOfood® is used for the dietary management of gastrointestinal, muscular and dermatological pathologies caused by DAO deficiency.

Although it is recommended to consume each tablet with a little water 20 minutes before each main meal (a total of 3 times a day: breakfast, lunch and dinner), because the activity of the DAO enzyme of DAOfood® is maintained for 4 -5 hours you can also consume each tablet a maximum of 2-3 hours before each meal.

The enzyme Diamine Oxidase (DAO) from DAOfood®  maintains its metabolic activity of food histamine for 4-5 hours after taking the supplement.

It can be consumed before a meal up to a maximum of 3 tablets, being advisable not to consume more than 3 tablets daily. In this way, if for having a meal rich in histamine in a day 2 or 3 tablets are consumed before it, it is advisable that if 2 tablets have been consumed, only one more tablet is consumed at the next meal during that day, and If 3 tablets have been consumed, do not consume any more tablets during that day.

The results of dietary management (reduction in the duration and intensity of the attacks, increase in the period between attacks and improvement in the rest of the gastrointestinal, skin and muscular symptoms produced by the DAO deficiency) begin to be appreciated after 15 days of the supplementation and within the first 30 days.

It is recommended to make an objective diagnosis of DAO deficiency, follow a diet low in histamine and take one capsule at least 3 times a day (consume a capsule 20 with a little water minutes before each main meal).

DAOfood® can be taken indefinitely, being suitable for diabetics, celiacs and / or people with food intolerance, it does not contain allergens, gluten, lactose, histamine or sugars, and it does not cause side effects, which is why it is recommended for the dietary management of migraine. and chronic headaches and the rest of gastrointestinal, skin and muscular pathologies associated with DAO deficiency.

Each tablet contains 0.3 mg of Diamine Oxidase (DAO) enzyme. It is recommended not to exceed a maximum daily dose of 12.6 mg of protein extract of pork kidney rich in DAO enzyme, therefore it is advisable to take a maximum of 3 tablets per day (each tablet contains 4.2 mg of protein extract of pig kidney rich in DAO enzyme).

The primary origin of DAO deficiency is due to genetic factors (DAO gene variants associated with low enzyme activity) and is diagnosed by the Diamine Oxidase (DAO) Activity Molecular Genetic Study (AOC1-V). It can be found in pharmacies specialized in DAO deficiency, online pharmacies and amazon.

The primary origin of DAO deficiency is due to genetic factors (DAO gene variants associated with low enzyme activity) and is diagnosed by the Diamine Oxidase (DAO) Activity Molecular Genetic Study (AOC1-V). It can be found in pharmacies specialized in DAO deficiency, online pharmacies and amazon.

The secondary origin of DAO deficiency may be due to the consumption of drugs that inhibit the enzyme DAO, the ingestion of foods rich in histamine and / or other biogenic amines, or the ingestion of foods that inhibit DAO, such as alcohol. Certain pathologies that affect the intestinal mucus, such as Crohn’s Disease, Ulcerative Colitis and intestinal operations are also at the origin of the DAO deficiency. For the diagnosis of these secondary causes, an analysis of DAO activity in plasma is performed. This analysis can be requested and performed in public and private hospitals.

    Accept the privacy policy

    Available in pharmacies specialized in DAO deficiency. You can also buy it in online pharmacies and on amazon.

    32,50 £ (VAT included)    FREE Shipping.

    Receive it in 1 day with Prime.

    Related Products


    Dietary management

    Gastrointestinal, skin and muscular pathologies associated to DAO deficiency / Histamine Intolerance.

    DAO enzyme.


    60 gastro-resistant mini-tablets.



    Dietary management

    Migraine, headache and tinnitus caused by DAO deficiency / Histamine Intolerance.

    DAO enzyme, Vitamin B (B6,B9, B12) and Caffeine.


    60 capsules with gastro-resistant tablets.


    Molecular Genetics Study of Diamine Oxidase (DAO) Enzyme Activity (AO1C-V)


    PCR diagnosis of the primary genetic origin of DAO deficiency / Histamine Intolerance.

    Extraction material and shipment of DNA samples.


    Informed consent

    2 swabs for sample extraction

    Postage paid envelope



    Diagnosis of the secondary origin of DAO deficiency / Histamine Intolerance.

    Available in


    Medical Centers

    Customized DAO Enzyme solutions

    Dietary management and food processing

    DAO enzyme for the food, veterinary and animal health industries.

    DiAmine Oxidase (DAO) Enzyme.


    Customized solutions

    Follow us on social media

    Press releases and media news

    New Regulatory Approvals Support DAO Deficiency Solution Expansion

    In February 2022, the active ingredient diamine oxidase – or DAO – produced by AB Biotek’s DR Healthcare division, as well as the solutions derived from it, have obtained the GRAS (Generally Recognized As Safe, per sections 201(s) and 409 of the U.S. Food & Drug Act) qualification from the U.S. Food & Drug Administration.  This allows for the upcoming...

    Scientific and clinical evidence

    Serum Diamine Oxidase Values, Indicating Histamine Intolerance, Influence Lactose Tolerance

    Download the paper clicking here Abstract: Lactose intolerance (LIT) is one of the major causes of irritable bowel syndrome (IBS) spectrum complaints. Differences in inadequate lactose digestion are described as various LIT phenotypes with basically unknown pathophysiology. In LIT patients, we retrospectively assessed the effect of histamine intolerance (HIT)...


    Not only does the coronavirus alter Christmas

    The Coronavirus has altered our lives. And it will also alter this Christmas, which will undoubtedly be different. Still, some things are not going to change compared to the Christmas holidays of other years: emotions increase, alcohol is exceeded, meals are exaggerated and, consequently, many people will have heavy digestion, flatulence, a feeling of bloating,...

    Activities and events


    Next Monday 17 June (2019), will take place from 14.00 to 16.00 hours in the University Rovira i Virgili (Edifici N5 Sustainable Chemistry, Assembly Hall.Marcel.li Sunday, 2-4-6, Sescelades Campus 43007-Tarragona, Spain) the training activity “DAO deficiency and the role of the pharmacist in the diagnosis and treatment” (language: Spanish). This training is organized...