Effect of dietary fatty acid and micronutrient intake/energy ratio on serum diamine oxidase activity in healthy women

Serum diamine oxidase (DAO) activity varies to a greater extent in women than in men. DAO activity during the luteal phase was higher than that during the follicular phase in healthy women. Recent reports have indicated that duodenal lipid infusion increased DAO activity in the intestinal lymph in rats.

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Nutrition. 2017 Jul – Aug;39-40:67-70. doi: 10.1016/j.nut.2017.03.004. Epub 2017 Mar 28.

Miyoshi M¹, Ueno M¹, Matsuo M¹, Hamada Y², Takahashi M³, Yamamoto M³, Yamamoto I³, Mikajiri R³, Tabuchi S³, Wakida K³, Yamanishi M³, Hirai M³, Usami M⁴.

Author information

1: Division of Nutrition and Metabolism, Kobe University Graduate School of Health Sciences, Kobe, Japan.
2: Department of Therapeutic Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
3: Department of Nutrition, Kobe University Hospital, Kobe University School of Medicine, Kobe, Japan.
4: Division of Nutrition and Metabolism, Kobe University Graduate School of Health Sciences, Kobe, Japan; Department of Nutrition, Kobe University Hospital, Kobe University School of Medicine, Kobe, Japan. Electronic address: musa@kobe-u.ac.jp.

Abstract

OBJECTIVE:

Serum diamine oxidase (DAO) activity varies to a greater extent in women than in men. DAO activity during the luteal phase was higher than that during the follicular phase in healthy women. Recent reports have indicated that duodenal lipid infusion increased DAO activity in the intestinal lymph in rats. The aim of this study was to elucidate the effect of dietary nutrient intake on serum DAO activity in healthy women.

METHODS:

Thirty-four healthy Japanese women were recruited. Food surveys were performed using dietary records for 3 d during both the follicular and luteal phases. Nutrient intake was calculated and expressed as the energy intake ratio. The correlation between DAO activity and nutrient intake was analyzed.

RESULTS:

Serum DAO activity in both phases was positively correlated with intake of long-chain fatty acids, saturated fatty acids, and monounsaturated fatty acids (P < 0.05). Intake of phosphorus, calcium, zinc, magnesium, iron, and vitamin B₁₂ during the luteal phase was positively correlated with serum DAO activity (P < 0.05).

CONCLUSION:

In healthy women, serum DAO activity was influenced by dietary fatty acid and micronutrient intake.

KEYWORDS:

Dietary fatty acids; Dietary micronutrients; Long-chain fatty acids; Menstrual cycle; Serum diamine oxidase activity

PMID:: 28606572
DOI:: 10.1016/j.nut.2017.03.004