Intestinal Dysbiosis in Patients with Histamine Intolerance
New study published about microbiota, histamine intolerance and DAO deficiency by the research team of the University of Barcelona (Dr. Mª Carmen Vidal). Adding clinical and scientific evidence every day.
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Abstract: An underlying cause of histamine intolerance is diamine oxidase (DAO) deficiency, which leads to defective homeostasis and a higher systemic absorption of histamine. Impaired DAO activity may have a genetic, pharmacological or pathological origin. A recent proposal also suggests it can arise from an alteration in the gut microbiota, although only one study has explored this hypothesis to date. A greater abundance of histamine-secreting bacteria in the gut could lead to the development of histamine ntolerance. Thus, the aim of this study was to characterize the composition of the intestinal microbiota of patients with histamine intolerance symptoms and compare it with that of healthy individuals. The study was performed by sequencing bacterial 16S rRNA genes (V3-V4 region) and analyzing the data using the EzBioCloud Database. Dysbiosis of the gut microbiota was observed in the histamine intolerance group who, in comparison with the healthy individuals, had a significantly lower proportion of Prevotellaceae, Ruminococcus, Faecalibacterium and Faecablibacterium prausnitzii, which are bacteria related to gut health. They also had a significantly higher abundance of histaminesecreting bacteria, including the genera Staphylococcus and Proteus, several unidentified genera belonging to the family Enterobacteriaceae and the species Clostridium perfringens and Enterococcus faecalis. A greater abundance of histaminogenic bacteria would favor the accumulation of high levels of histamine in the gut, its subsequent absorption in plasma and the appearance of adverse effects, even in individuals without DAO deficiency.
Sònia Sánchez-Pérez 1,2,3 , Oriol Comas-Basté 1,2,3 , Adriana Duelo 1,2,3, M. Teresa Veciana-Nogués 1,2,3 ,
Mercedes Berlanga 4 , M. Luz Latorre-Moratalla 1,2,3,† and M. Carmen Vidal-Carou 1,2,3,*,†
1 Department de Nutrició, Ciències de l’Alimentació i Gastronomía, Facultat de Farmàcia i Ciències de l’Alimentació, Campus de l’Alimentació de Torribera, Universitat de Barcelona (UB), Av. Prat de la Riba 171, 08921 Santa Coloma de Gramenet, Spain; soniasanchezperez@ub.edu (S.S.-P.); oriolcomas@ub.edu (O.C.-B.); aduelo@ub.edu (A.D.); veciana@ub.edu (M.T.V.-N.); mariluzlatorre@ub.edu (M.L.L.-M.)
2 Institut de Recerca en Nutrició i Seguretat Alimentària (INSAUB), Universitat de Barcelona (UB), Av. Prat de la Riba 171, 08921 Santa Coloma de Gramenet, Spain
3 Xarxa d’Innovació Alimentària (XIA), C/Baldiri Reixac 4, 08028 Barcelona, Spain
4 Departament de Biologia, Sanitat i Mediambient, Secció de Microbiologia, Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona (UB), Av. Joan XXIII 27-31, 08028 Barcelona, Spain; mberlanga@ub.edu
- Correspondence: mcvidal@ub.edu
† These authors contributed equally to this work.
Citation: Sánchez-Pérez, S.; Comas-Basté, O.; Duelo, A.; Veciana-Nogués, M.T.; Berlanga, M.; Latorre-Moratalla, M.L.; Vidal-Carou, M.C. Intestinal Dysbiosis in Patients with Histamine Intolerance. Nutrients 2022, 14, 1774. https://doi.org/10.3390/nu14091774
Not only does the coronavirus alter Christmas
The Coronavirus has altered our lives. And it will also alter this Christmas, which will undoubtedly be different. Still, some things are not going to change compared to the Christmas holidays of other years: emotions increase, alcohol is exceeded, meals are exaggerated and, consequently, many people will have heavy digestion, flatulence, a feeling of bloating, contractures, hangover, headache and even migraine.
Histamine in Christmas foods
And it is not only COVID-19 alters Christmas. A molecule present in most “Christmas” foods is related with all these symptoms and also alters our lives. Is the histamine, a molecule necessary for life but that in excess becomes “perverse”. An amine that is especially present and abundant in the foods consumed at Christmas parties: by tradition, Christmas is accompanied by certain foods with a high concentration of histamine such as canapes, appetizers with sausages, smoked meats, assorted sauces such as the bechamel of the cannelloni or the tartar sauce of the fish; seafood, canned foods such as anchovies, spices such as curry or cinnamon, nougats, polvorones or roscón de reyes, cava, champagne and other alcoholic beverages.
DAO enzyme to avoid its effects
The Diamine Oxidase or DAO enzyme is responsible for metabolizing or degrading the histamine ingested through these foods. However, in these days of dietary excesses DAO activity is saturated or even inhibited by alcohol, so our best recommendation is to prevent the appearance of these symptoms by previously supplementing Christmas menus with DAO enzyme.
This measure is also advisable for those people who spend Christmas at home having tested positive for their last coronavirus test. Published studies indicate that SAR COV-2 infection causes a release of cytokines from mast cells, accompanied by a release of endogenous histamine, which may justify the triggering of some of the symptoms, so it is advisable to control the entry routes of dietary histamine or guarantee its degradation by taking DAO preventively to avoid further accumulation in plasma.
Our DAO products
DAOfood® and DAOfood® Plus are biological DAO enzyme supplements that increase the degradation capacity of dietary histamine. Its intake prevents the absorption and accumulation of circulating histamine and also counteracts the release of endogenous histamine as a reaction of the body when it comes into contact with the virus.
DR Healthcare wishes you a Happy Holidays!
References:
Kritas, S. K., Ronconi, G., Caraffa, A., Gallenga, C. E., Ross, R., & Conti, P. (2020). Mast cells contribute to coronavirus-induced inflammation: new anti-inflammatory strategy. Journal of biological regulators and homeostatic agents, 34(1), 10.23812/20-Editorial-Kritas.