According to a study the 90% of migraines can be treated with the enzyme DAO – Interview of RTVE to Juanjo Duelo, CEO of DR Healthcare
7/3/2013 – interview to Juanjo Duelo in rtve 24h. Language: Spanish
These last hours has been spoken about migraines, from which has been made public that the fifteen percent of the world’s population suffers from these tremendous headaches that go beyond a headache. Juanjo Duelo, in addition to suffering from migraines, directs a research team that assures to be able to determine the causes of migraines and most importantly, their solution.
“Our market is the world and we began to be an international reference” – interview in eduscopi to Juanjo Duelo, CEO of DR Healthcare
8/5/2019 – original interview published in eduscopi
The patient Congressman
Affected by strong migraines for many years, Juanjo Duelo, who was dedicated to the world of finance, decided to start to learn first-hand the latest research about this symptom who accompanied him from quite young.
He began to attend medical conferences that addressed the topic of migraine and compared the information he received to that provided by the tests conducted on him his self as a patient at home.
He began to control his diet and saw that between the food and the migraine had some kind of relationship. Determined to find a solution to his problem and for millions of people, looked for researchers that endorse his hypothesis. Twelve years after he created DR Healthcare company with more than 80 patents and now it is a reference on the study of the DAO enzyme.
What prompted the creation, twelve years ago, of DR Healthcare?
We were born as a start-up of the University of Barcelona (UB), always linked to the Department of Nutrition and we seek in the world of academia if there was any research team with interest in our project. We wanted to find some scientific basis that will find the relationship between food and migraine, because until then we had no physiological or chemical explanation to explain this relationship.
Our market is the world and we began to be an international reference” – Juanjo Duelo, CEO of DR Healthcare
What was behind your research?
Doing research on histamine , which is a key molecule in our body because it regulates many functions. The problem is that the same molecule also forms in most of the foods from the diet, and the histamine that everyday we consume with food does not have a physiological function such as the produced by the body. This makes that when it reaches the intestine being degraded, metabolized and eliminated and not absorbed. In this context, a key enzyme in the metabolism of histamine is called Diamine Oxidase (DAO).
There are people who by a motive, mainly genetic, cannot degrade the histamine that ingest from food, and, like is not metabolised, it is absorbed through the intestinal epithelium and then enters the bloodstream and accumulates in the blood. There are individuals who accumulate histamine in the blood faster than others, and there are several others who suffer symptoms earlier than others. But it was never linked before to food because the relationship between you eat the food and the appearance of symptoms does not occur immediately.
In the year 2010 we published the first study that showed that more than 90% of migraine patients had a genetic variation that produces a deficiency in the activity of diamine oxidase enzyme.
Is it being a very productive line of research?
The field of migraine is where we have generated more scientific evidence, that is our main concern. We move in the field of medical nutrition, which is to tackle diseases through nutrition, and we need scientific evidence before looking for the clinical evidence. After publishing many studies on migraine and headaches, now we focus a lot on fibromyalgia or ADHD (Attention Deficit Hyperactivity Disorder).
What is the solution the company offers to those affected by migraine headaches or symptoms associated to the DAO deficiency?
From a clinical point of view, people who have a DAO deficiency, their track therapy is twofold: on the one hand dietetic, controlling the intake of histamine and other secondary amines. And, depending on the activity level of DAO, other path is, at least in the first stage, restore, replace or complement DAO. And this is where we work in the DAO form animal, plant or biotechnology origin. We speak of very prevalent diseases (migraine, ADHD, fibromyalgia…) and we treat them as symptoms.
Over these 12 years of life where has evolved DR Healthcare?
Now we have abandoned the main focus of migraine and guide our research to the DAO and its role as a biomarker.
And you have decided to get out of Barcelona and seek alliances with the University Rovira i Virgili (URV) through a new R&D&i center in Tarragona
Accurate. The relationship with the UB is really satisfactory for us, but now we have also been attracted by the dynamism of the URV and we think that complement each other well . And in front of the need for growth of the company, we saw that we needed to boost an ambitious center with pilot tests with this enzyme, always with the premise that we didn’t want to leave Catalonia. We are an innovative company that begins to be an international reference and we believe that the relationship with the URV is a good option. With the URV Foundation we want to promote research projects jointly with other areas or departments of the University, always linked to the DAO. This is why who is leading this project is Jaume Bori, a graduate in biotechnology at the URV. He directs the Center for R+D+i and works to turn it into a reference center from where we will promote various projects. Over the years we have become a singular company, since we are the only specialists in DAO and its mainly deficiency and associated symptoms.
We have generated more than 80 patents, all with the enzyme DAO, and we are the only company that has this asset.
What functions assumes the center of Tarragona?
We want to complement the investigation initiated in the UB on DAO of plant origin, and also recombinant DAO. And the more immediate objectives are to begin looking for connectivities in the campus and within the scope of the University in order to find synergies and projects in other areas. At the moment, the forecast is to dedicate a 70% of the activity to research and a 20% to the production of the enzyme.
Which is your market?
Our market is the world. We have generated more than 80 patents, all with the enzyme DAO, and we are the only company that has this asset.
To access the original interview in catalan clic here.
The past 17 November 2018 took place in Orense the training on deficit of DAO (diamine oxidase) given by the dietician-nutritionist Adriana Duelo and organized by CODINUGAL (Official College of Dieticians-nutritionists of Galicia).
The training consisted in:
– First part of introduction in which she spoke about what is the Histamine, its metabolism and the symptoms of the DAO Deficiency.
– The second part in which was addressed the scientific evidence and was analyzed a real case .
– And a last part to resolve the doubts of the attendees.
Here we present you the interview given by the dietician-nutritionist Adriana Duelo to the Communication Commission of CODINUGAL. Adriana Duelo is one of the largest international experts in this area of the nutritional medicine, since the DAO deficiency is a metabolic disorder with genetic bases that has dietary and food treatments for a large number of their symptoms: “migraine”, “Irritable Bowel Syndrome”, “fibromyalgia”, “vascular headaches”, “atopic dermatitis”, “muscle aches.”
INTERVIEW TO ADRIANA DUELO – DEFICIT OF DAO
“The science together with experience are the best formations.”
Why did you decide to specialize in deficit of DAO?
Because in my family are several who suffer deficit of DAO and we knew it when I was cursed 3º of NH (Human Nutrition) and D (Dietetics) at the University. So I decided to make my end of career work on the subject and I ended up specialing. Today 90% of patients who I visit have this disorder in the metabolism of histamine.
What kind of specific training is in this field?
Very little, […]is a specialty so young still has no formal training. So there is no other that autotraining […] Science together with experience are the best formations.
What type of patients are the ones that come to your consult? all of them have common symptoms?[…]Suffer from dyspepsia (digestion disorder that appears after meals and whose symptoms are nausea, heaviness and pain in the stomach, heartburn and flatulence), migraine and symptoms of allergies […]how rhinitis or urticaria. The picture of a person suffering deficit of DAO includes more than 2 or 3 symptoms normally, all derived from an excess of histamine by not being able to degrade it in a correct way. […] We also see patients with muscle aches and chronic fatigue (often diagnosed of fibromyalgia), hyperactive children and with attention deficit (much diagnosed with ADHD), menstrual pains that improve or disappear with treatment and other symptoms less common.
What analytical parameters are used to detect deficit of DAO?
Currently there is only one way to assess the activity of the enzyme diamine oxidase, which is through a blood analysis and can be performed in most laboratories. There is a genetic profile test to find out if there’s bias. It values if they are affected some of the 4 known polymorphisms of the DAO gene .
On the other hand, research teams are developing protocols to be detected using a urine sample, a fact that would be much simpler and faster.
Can it be cured?
I don’t like to talk about healing, because it is difficult to assert it with total security. […] what you can is to control the symptoms, which in the end is what matters to the patient.
The DAO Deficiency can be derived from a genetic mutation or due to a surgical intervention and never be recovered, but there are also people who have deficit of DAO acquired by consumption of certain drugs blockers of the enzyme, inflammatory bowel disease or consumption of alcoholic beverages, among others. In these cases you can greatly improve the activity with appropriate treatment. The vast majority of patients have a genetic factor, but equally become them who control their symptoms and not vice versa.
In addition to Diototerapia recommends any supplement or medication?
It is indispensable at the beginning and in the long run. We recommend you take enzyme diamine oxidase, a food for special medical purposes which facilitates the metabolism of histamine food security during the digestion and allows you to be able to follow a diet something less restrictive.
What are the most important recommendations in terms of Dietherapy?[…]Remove cold meats, dairy products, citrus, alcohol. […] Are found in most foods to one extent or another. So it would be the best to receive personalized advice to achieve success without falling into a diet too restrictive and little nutritious.
The focus of the nutritional medicine is one of the greatest advances that western medicine has been incorporated in recent decades. This discipline involves nutrition and dietetics within the complex system of causes and effects that generate disorders and diseases, but also health.
*New foods and supplements
In this way, new foods and nutritional supplements, such as the use of certain enzymes in patients with deficits, or pre-, pro- and post-biotics, allow you to rebalance alterations caused by external factors, but also internal, own of the individual.
We are referring to both genetic diseases as to diseases and physiological disorders, and taking into consideration the fact that these can be developed or exacerbated by exposure to avoidable elements of our environment, or our habits.
*Potential and reality
From this interview is distilled the potential and the reality of this science: developing new alternative treatments to the current pharmacopoeia; more consistent and durable, without seeking immediate effects through substances that alter deeply the balance of the organism; and providing innovative qualities, without side effects and that form the basis of the relationship so palpable between health and food.
This interview is located within the newsletter of CODINUGAL, drawn up by the Communication Commission of this collegiality and published in January 2019. You can access the pdf of the newsletter through this link (the document is in spanish).
If you would like more information, access via the following links to content about DAO Deficiency, causes and origin, which are rich histamine foods, which foods produce endogenous histamine release or act as blockers of the Diamine Oxidase activity.